Poly(A) tail length regulates PABPC1 expression to tune translation in the heart

The rate of protein synthesis in the adult heart is one of the lowest in mammalian tissues, but it increases substantially in response to stress and hypertrophic stimuli through largely obscure mechanisms. Here, we demonstrate that regulated expression of cytosolic poly(A)-binding protein 1 (PABPC1)...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Chorghade, Sandip, Seimetz, Joseph, Emmons, Russell, Yang, Jing, Bresson, Stefan M, Lisio, Michael De, Parise, Gianni, Conrad, Nicholas K, Kalsotra, Auinash
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2017
Pynciau:
Biochemistry
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487213/
https://ncbi.nlm.nih.gov/pubmed/28653618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.24139
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