Poly(A) tail length regulates PABPC1 expression to tune translation in the heart

The rate of protein synthesis in the adult heart is one of the lowest in mammalian tissues, but it increases substantially in response to stress and hypertrophic stimuli through largely obscure mechanisms. Here, we demonstrate that regulated expression of cytosolic poly(A)-binding protein 1 (PABPC1)...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Chorghade, Sandip, Seimetz, Joseph, Emmons, Russell, Yang, Jing, Bresson, Stefan M, Lisio, Michael De, Parise, Gianni, Conrad, Nicholas K, Kalsotra, Auinash
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2017
Fag:
Biochemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487213/
https://ncbi.nlm.nih.gov/pubmed/28653618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.24139
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