Poly(A) tail length regulates PABPC1 expression to tune translation in the heart

The rate of protein synthesis in the adult heart is one of the lowest in mammalian tissues, but it increases substantially in response to stress and hypertrophic stimuli through largely obscure mechanisms. Here, we demonstrate that regulated expression of cytosolic poly(A)-binding protein 1 (PABPC1)...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:eLife
Egile Nagusiak: Chorghade, Sandip, Seimetz, Joseph, Emmons, Russell, Yang, Jing, Bresson, Stefan M, Lisio, Michael De, Parise, Gianni, Conrad, Nicholas K, Kalsotra, Auinash
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications, Ltd 2017
Gaiak:
Biochemistry
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487213/
https://ncbi.nlm.nih.gov/pubmed/28653618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.24139
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