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Intratumoral delivery of tumor antigen-loaded DC and tumor-primed CD4(+) T cells combined with agonist α-GITR mAb promotes durable CD8(+) T-cell-dependent antitumor immunity

The progressive tumor microenvironment (TME) coordinately supports tumor cell expansion and metastasis, while it antagonizes the survival and (poly-)functionality of antitumor T effector cells. There remains a clear need to develop novel therapeutic strategies that can transform the TME into a pro-i...

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Bibliografiska uppgifter
I publikationen:	Oncoimmunology
Huvudupphovsmän:	Liu, Zuqiang, Hao, Xingxing, Zhang, Yi, Zhang, Jiying, Carey, Cara D., Falo, Louis D., Storkus, Walter J., You, Zhaoyang
Materialtyp:	Artigo
Språk:	Inglês
Publicerad:	Taylor & Francis 2017
Ämnen:	Original Research
Länkar:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5486177/ https://ncbi.nlm.nih.gov/pubmed/28680744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1315487
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Intratumoral delivery of tumor antigen-loaded DC and tumor-primed CD4(+) T cells combined with agonist α-GITR mAb promotes durable CD8(+) T-cell-dependent antitumor immunity

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