Intratumoral delivery of tumor antigen-loaded DC and tumor-primed CD4(+) T cells combined with agonist α-GITR mAb promotes durable CD8(+) T-cell-dependent antitumor immunity

The progressive tumor microenvironment (TME) coordinately supports tumor cell expansion and metastasis, while it antagonizes the survival and (poly-)functionality of antitumor T effector cells. There remains a clear need to develop novel therapeutic strategies that can transform the TME into a pro-i...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Oncoimmunology
Hauptverfasser: Liu, Zuqiang, Hao, Xingxing, Zhang, Yi, Zhang, Jiying, Carey, Cara D., Falo, Louis D., Storkus, Walter J., You, Zhaoyang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2017
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5486177/
https://ncbi.nlm.nih.gov/pubmed/28680744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1315487
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