Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3(+)CD25(+)CD4(+) regulatory T cells

Eitemau Tebyg

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• Therapeutic Immunity by Adoptive Tumor-primed CD4(+) T-cell Transfer in Combination With In Vivo GITR Ligation
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• Anti-CCR4 mAb selectively depletes effector-type FoxP3(+)CD4(+) regulatory T cells, evoking antitumor immune responses in humans
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  Cyhoeddwyd: (2013)
• The origin of FOXP3-expressing CD4(+) regulatory T cells: thymus or periphery
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• Immunologic Self-Tolerance Maintained by Cd25(+)Cd4(+)Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4
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