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Anti-CCR4 mAb selectively depletes effector-type FoxP3(+)CD4(+) regulatory T cells, evoking antitumor immune responses in humans
CD4(+) Treg cells expressing the transcription factor FOXP3 (forkhead box P3) are abundant in tumor tissues and appear to hinder the induction of effective antitumor immunity. A substantial number of T cells, including Treg cells, in tumor tissues and peripheral blood express C-C chemokine receptor...
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| 主要な著者: | , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3816454/ https://ncbi.nlm.nih.gov/pubmed/24127572 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1316796110 |
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