Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3(+)CD25(+)CD4(+) regulatory T cells

T cell stimulation via glucocorticoid-induced tumor necrosis factor receptor family–related protein (GITR) can evoke effective tumor immunity. A single administration of agonistic anti-GITR monoclonal antibody (mAb) to tumor-bearing mice intravenously or directly into tumors provoked potent tumor-sp...

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Detalhes bibliográficos
Main Authors: Ko, Kuibeom, Yamazaki, Sayuri, Nakamura, Kyoko, Nishioka, Tomohisa, Hirota, Keiji, Yamaguchi, Tomoyuki, Shimizu, Jun, Nomura, Takashi, Chiba, Tsutomu, Sakaguchi, Shimon
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213162/
https://ncbi.nlm.nih.gov/pubmed/16186187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050940
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