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T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17(+) Th cells that cause autoimmune arthritis
This report shows that highly self-reactive T cells produced in mice as a result of genetically altered thymic T cell selection spontaneously differentiate into interleukin (IL)-17–secreting CD4(+) helper T (Th) cells (Th17 cells), which mediate an autoimmune arthritis that clinically and immunologi...
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| Hoofdauteurs: | , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
The Rockefeller University Press
2007
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2118414/ https://ncbi.nlm.nih.gov/pubmed/17227914 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20062259 |
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