T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17(+) Th cells that cause autoimmune arthritis

This report shows that highly self-reactive T cells produced in mice as a result of genetically altered thymic T cell selection spontaneously differentiate into interleukin (IL)-17–secreting CD4(+) helper T (Th) cells (Th17 cells), which mediate an autoimmune arthritis that clinically and immunologi...

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Detalhes bibliográficos
Main Authors: Hirota, Keiji, Hashimoto, Motomu, Yoshitomi, Hiroyuki, Tanaka, Satoshi, Nomura, Takashi, Yamaguchi, Tomoyuki, Iwakura, Yoichiro, Sakaguchi, Noriko, Sakaguchi, Shimon
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
Assuntos:
Brief Definitive Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118414/
https://ncbi.nlm.nih.gov/pubmed/17227914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20062259
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