Complement drives Th17 cell differentiation and triggers autoimmune arthritis

Activation of serum complement triggers Th17 cell–dependent spontaneous autoimmune disease in an animal model. In genetically autoimmune-prone SKG mice, administration of mannan or β-glucan, both of which activate serum complement, evoked Th17 cell–mediated chronic autoimmune arthritis. C5a, a chief...

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Detalhes bibliográficos
Main Authors: Hashimoto, Motomu, Hirota, Keiji, Yoshitomi, Hiroyuki, Maeda, Shinji, Teradaira, Shin, Akizuki, Shuji, Prieto-Martin, Paz, Nomura, Takashi, Sakaguchi, Noriko, Köhl, Jörg, Heyman, Birgitta, Takahashi, Minoru, Fujita, Teizo, Mimori, Tsuneyo, Sakaguchi, Shimon
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2010
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882841/
https://ncbi.nlm.nih.gov/pubmed/20457757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20092301
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