Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis

Despite the importance of Th17 cells in autoimmune diseases, it remains unclear how they control other inflammatory cells in autoimmune tissue damage. Using a model of spontaneous autoimmune arthritis, we showed that arthritogenic Th17 cells stimulated fibroblast-like synoviocytes via interleukin-17...

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Publicat a:Immunity
Autors principals: Hirota, Keiji, Hashimoto, Motomu, Ito, Yoshinaga, Matsuura, Mayumi, Ito, Hiromu, Tanaka, Masao, Watanabe, Hitomi, Kondoh, Gen, Tanaka, Atsushi, Yasuda, Keiko, Kopf, Manfred, Potocnik, Alexandre J., Stockinger, Brigitta, Sakaguchi, Noriko, Sakaguchi, Shimon
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6024031/
https://ncbi.nlm.nih.gov/pubmed/29802020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.04.009
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