Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury

Cholestasis is associated with accumulation of bile acids and lipids, and liver injury. The constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are xenobiotic nuclear receptors that coordinate protective hepatic responses to potentially toxic stimuli, including bile acids. We invest...

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Main Authors: Stedman, Catherine A. M., Liddle, Christopher, Coulter, Sally A., Sonoda, Junichiro, Alvarez, Jacqueline G. A., Moore, David D., Evans, Ronald M., Downes, Michael
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2005
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC548592/
https://ncbi.nlm.nih.gov/pubmed/15684063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409794102
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