Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites

Efficient detoxification and clearance of cholesterol metabolites such as oxysterols, bile alcohols, and bile acids are critical for survival because they can promote liver and cardiovascular disease. We report here that loss of the nuclear xenobiotic receptor PXR (pregnane X receptor), a regulator...

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Autors principals: Sonoda, Junichiro, Chong, Ling Wa, Downes, Michael, Barish, Grant D., Coulter, Sally, Liddle, Christopher, Lee, Chih-Hao, Evans, Ronald M.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2005
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC548561/
https://ncbi.nlm.nih.gov/pubmed/15671183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409481102
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