Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites

Efficient detoxification and clearance of cholesterol metabolites such as oxysterols, bile alcohols, and bile acids are critical for survival because they can promote liver and cardiovascular disease. We report here that loss of the nuclear xenobiotic receptor PXR (pregnane X receptor), a regulator...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sonoda, Junichiro, Chong, Ling Wa, Downes, Michael, Barish, Grant D., Coulter, Sally, Liddle, Christopher, Lee, Chih-Hao, Evans, Ronald M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC548561/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15671183/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0409481102
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