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Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites
Efficient detoxification and clearance of cholesterol metabolites such as oxysterols, bile alcohols, and bile acids are critical for survival because they can promote liver and cardiovascular disease. We report here that loss of the nuclear xenobiotic receptor PXR (pregnane X receptor), a regulator...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC548561/ https://ncbi.nlm.nih.gov/pubmed/15671183 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409481102 |
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