Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR)

The nuclear receptor PXR (pregnane X receptor) protects the body from hepatotoxicity of secondary bile acids such as lithocholic acid (LCA) by inducing expression of the hydroxylating cytochrome P450 enzyme CYP3A and promoting detoxification. We found that activation of PXR also increases the activi...

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Main Authors: Sonoda, Junichiro, Xie, Wen, Rosenfeld, John M., Barwick, Joyce L., Guzelian, Philip S., Evans, Ronald M.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2002
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC129778/
https://ncbi.nlm.nih.gov/pubmed/12370413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.212494599
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