Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor

Through a multiplex promoter spanning 218 kb, the phase II UDP-glucuronosyltransferase 1A (UGT1) gene encodes at least eight differently regulated mRNAs whose protein products function as the principal means to eliminate a vast array of steroids, heme metabolites, environmental toxins, and drugs. Th...

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Autores principales: Xie, Wen, Yeuh, Mei-Fei, Radominska-Pandya, Anna, Saini, Simrat P. S., Negishi, Yoichi, Bottroff, Bobbie Sue, Cabrera, Geraldine Y., Tukey, Robert H., Evans, Ronald M.
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 2003
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC153063/
https://ncbi.nlm.nih.gov/pubmed/12644700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0438010100
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