Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor

Through a multiplex promoter spanning 218 kb, the phase II UDP-glucuronosyltransferase 1A (UGT1) gene encodes at least eight differently regulated mRNAs whose protein products function as the principal means to eliminate a vast array of steroids, heme metabolites, environmental toxins, and drugs. Th...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Xie, Wen, Yeuh, Mei-Fei, Radominska-Pandya, Anna, Saini, Simrat P. S., Negishi, Yoichi, Bottroff, Bobbie Sue, Cabrera, Geraldine Y., Tukey, Robert H., Evans, Ronald M.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2003
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153063/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12644700/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0438010100
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