p62/SQSTM1 cooperates with hyperactive mTORC1 to regulate glutathione production, maintain mitochondrial integrity and promote tumorigenesis

p62/sequestosome-1 (SQSTM1) is a multifunctional adaptor protein and autophagic substrate which accumulates in cells with hyperactive mTORC1, such as kidney cells with mutations in the tumor suppressor genes TSC1 or TSC2. Here we report that p62 is a critical mediator of TSC2-driven tumorigenesis, a...

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Pubblicato in:Cancer Res
Autori principali: Lam, Hilaire C., Baglini, Christian V., Lope, Alicia Llorente, Parkhitko, Andrey A., Liu, Heng-Jia, Alesi, Nicola, Malinowska, Izabela A., Ebrahimi-Fakhari, Darius, Saffari, Afshin, Yu, Jane J., Pereira, Ana, Khabibullin, Damir, Ogorek, Barbara, Nijmeh, Julie, Kavanagh, Taylor, Handen, Adam, Chan, Stephen Y., Asara, John M., Oldham, William M., Diaz-Meco, Maria T., Moscat, Jorge, Sahin, Mustafa, Priolo, Carmen, Henske, Elizabeth P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5485875/
https://ncbi.nlm.nih.gov/pubmed/28512249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2458
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