High-throughput drug screen identifies chelerythrine as a selective inducer of death in a TSC2-null setting

Tuberous sclerosis complex (TSC) is an autosomal dominant syndrome associated with tumors of the brain, heart, kidney, and lung. The TSC protein complex inhibits the mammalian or mechanistic target of Rapamycin complex 1 (mTORC1). Inhibitors of mTORC1, including Rapamycin, induce a cytostatic respon...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Medvetz, Doug, Sun, Yang, Li, Chenggang, Khabibullin, Damir, Balan, Murugabaskar, Parkhitko, Andrey, Priolo, Carmen, Asara, John, Pal, Soumitro, Yu, Jane, Henske, Elizabeth P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4312508/
https://ncbi.nlm.nih.gov/pubmed/25185584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-14-0440
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