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High-throughput drug screen identifies chelerythrine as a selective inducer of death in a TSC2-null setting
Tuberous sclerosis complex (TSC) is an autosomal dominant syndrome associated with tumors of the brain, heart, kidney, and lung. The TSC protein complex inhibits the mammalian or mechanistic target of Rapamycin complex 1 (mTORC1). Inhibitors of mTORC1, including Rapamycin, induce a cytostatic respon...
שמור ב:
| הוצא לאור ב: | Mol Cancer Res |
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| Main Authors: | , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2014
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4312508/ https://ncbi.nlm.nih.gov/pubmed/25185584 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-14-0440 |
| תגים: |
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