p62/SQSTM1 cooperates with hyperactive mTORC1 to regulate glutathione production, maintain mitochondrial integrity and promote tumorigenesis

p62/sequestosome-1 (SQSTM1) is a multifunctional adaptor protein and autophagic substrate which accumulates in cells with hyperactive mTORC1, such as kidney cells with mutations in the tumor suppressor genes TSC1 or TSC2. Here we report that p62 is a critical mediator of TSC2-driven tumorigenesis, a...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Cancer Res
Hlavní autoři: Lam, Hilaire C., Baglini, Christian V., Lope, Alicia Llorente, Parkhitko, Andrey A., Liu, Heng-Jia, Alesi, Nicola, Malinowska, Izabela A., Ebrahimi-Fakhari, Darius, Saffari, Afshin, Yu, Jane J., Pereira, Ana, Khabibullin, Damir, Ogorek, Barbara, Nijmeh, Julie, Kavanagh, Taylor, Handen, Adam, Chan, Stephen Y., Asara, John M., Oldham, William M., Diaz-Meco, Maria T., Moscat, Jorge, Sahin, Mustafa, Priolo, Carmen, Henske, Elizabeth P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5485875/
https://ncbi.nlm.nih.gov/pubmed/28512249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2458
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky