p62/SQSTM1 cooperates with hyperactive mTORC1 to regulate glutathione production, maintain mitochondrial integrity and promote tumorigenesis

p62/sequestosome-1 (SQSTM1) is a multifunctional adaptor protein and autophagic substrate which accumulates in cells with hyperactive mTORC1, such as kidney cells with mutations in the tumor suppressor genes TSC1 or TSC2. Here we report that p62 is a critical mediator of TSC2-driven tumorigenesis, a...

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書誌詳細
出版年:Cancer Res
主要な著者: Lam, Hilaire C., Baglini, Christian V., Lope, Alicia Llorente, Parkhitko, Andrey A., Liu, Heng-Jia, Alesi, Nicola, Malinowska, Izabela A., Ebrahimi-Fakhari, Darius, Saffari, Afshin, Yu, Jane J., Pereira, Ana, Khabibullin, Damir, Ogorek, Barbara, Nijmeh, Julie, Kavanagh, Taylor, Handen, Adam, Chan, Stephen Y., Asara, John M., Oldham, William M., Diaz-Meco, Maria T., Moscat, Jorge, Sahin, Mustafa, Priolo, Carmen, Henske, Elizabeth P.
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5485875/
https://ncbi.nlm.nih.gov/pubmed/28512249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2458
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