Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma

Chromophobe renal cell carcinoma (ChRCC) accounts for 5% of all sporadic renal cancers and can also occur in genetic syndromes including Birt–Hogg–Dube (BHD) and tuberous sclerosis complex (TSC). ChRCC has a distinct accumulation of abnormal mitochondria, accompanied by characteristic chromosomal im...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Priolo, Carmen, Khabibullin, Damir, Reznik, Ed, Filippakis, Harilaos, Ogórek, Barbara, Kavanagh, Taylor R., Nijmeh, Julie, Herbert, Zachary T., Asara, John M., Kwiatkowski, David J., Wu, Chin-Lee, Henske, Elizabeth P.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2018
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6142242/
https://ncbi.nlm.nih.gov/pubmed/29891694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710849115
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