Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression

Polycomb repressive complexes (PRCs) are important histone modifiers, which silence gene expression; yet, there exists a subset of PRC-bound genes actively transcribed by RNA polymerase II (RNAPII). It is likely that the role of Polycomb repressive complex is to dampen expression of these PRC-active...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Kar, Gozde, Kim, Jong Kyoung, Kolodziejczyk, Aleksandra A., Natarajan, Kedar Nath, Torlai Triglia, Elena, Mifsud, Borbala, Elderkin, Sarah, Marioni, John C., Pombo, Ana, Teichmann, Sarah A.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484669/
https://ncbi.nlm.nih.gov/pubmed/28652613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00052-2
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