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Characterizing noise structure in single-cell RNA-seq distinguishes genuine from technical stochastic allelic expression

Single-cell RNA-sequencing (scRNA-seq) facilitates identification of new cell types and gene regulatory networks as well as dissection of the kinetics of gene expression and patterns of allele-specific expression. However, to facilitate such analyses, separating biological variability from the high...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Kim, Jong Kyoung, Kolodziejczyk, Aleksandra A., Illicic, Tomislav, Teichmann, Sarah A., Marioni, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627577/
https://ncbi.nlm.nih.gov/pubmed/26489834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9687
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