Single Cell RNA-Sequencing of Pluripotent States Unlocks Modular Transcriptional Variation

Embryonic stem cell (ESC) culture conditions are important for maintaining long-term self-renewal, and they influence cellular pluripotency state. Here, we report single cell RNA-sequencing of mESCs cultured in three different conditions: serum, 2i, and the alternative ground state a2i. We find that...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Kolodziejczyk, Aleksandra A., Kim, Jong Kyoung, Tsang, Jason C.H., Ilicic, Tomislav, Henriksson, Johan, Natarajan, Kedar N., Tuck, Alex C., Gao, Xuefei, Bühler, Marc, Liu, Pentao, Marioni, John C., Teichmann, Sarah A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4595712/
https://ncbi.nlm.nih.gov/pubmed/26431182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.09.011
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