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R-Loops Enhance Polycomb Repression at a Subset of Developmental Regulator Genes
R-loops are three-stranded nucleic acid structures that form during transcription, especially over unmethylated CpG-rich promoters of active genes. In mouse embryonic stem cells (mESCs), CpG-rich developmental regulator genes are repressed by the Polycomb complexes PRC1 and PRC2. Here, we show that...
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| Udgivet i: | Mol Cell |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cell Press
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6414425/ https://ncbi.nlm.nih.gov/pubmed/30709709 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.12.016 |
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