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A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression
R loops are three-stranded nucleic acid structures that comprise nascent RNA hybridized with the DNA template, leaving the nontemplate DNA single-stranded. R loops form naturally during transcription even though their persistent formation can be a risky outcome with deleterious effects on genome int...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4083084/ https://ncbi.nlm.nih.gov/pubmed/24990962 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.242990.114 |
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