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Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome
The Polycomb Repressive Complexes PRC1 and PRC2 maintain embryonic stem cell (ESC) pluripotency by silencing lineage-specifying developmental regulator genes1. Emerging evidence suggests that Polycomb complexes act through controlling spatial genome organisation2–9. We show that PRC1 functions as a...
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Publicado no: | Nat Genet |
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4847639/ https://ncbi.nlm.nih.gov/pubmed/26323060 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3393 |
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