Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome

The Polycomb Repressive Complexes PRC1 and PRC2 maintain embryonic stem cell (ESC) pluripotency by silencing lineage-specifying developmental regulator genes1. Emerging evidence suggests that Polycomb complexes act through controlling spatial genome organisation2–9. We show that PRC1 functions as a...

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Publicat a:Nat Genet
Autors principals: Schoenfelder, Stefan, Sugar, Robert, Dimond, Andrew, Javierre, Biola-Maria, Armstrong, Harry, Mifsud, Borbala, Dimitrova, Emilia, Matheson, Louise, Tavares-Cadete, Filipe, Furlan-Magaril, Mayra, Segonds-Pichon, Anne, Jurkowski, Wiktor, Wingett, Steven W., Tabbada, Kristina, Andrews, Simon, Herman, Bram, LeProust, Emily, Osborne, Cameron S., Koseki, Haruhiko, Fraser, Peter, Luscombe, Nicholas M., Elderkin, Sarah
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4847639/
https://ncbi.nlm.nih.gov/pubmed/26323060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3393
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