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Cryo-EM structure of the open human ether-à-go-go related K(+) channel hERG
The human ether-à-go-go related potassium channel (hERG, Kv11.1) is a voltage-dependent channel known for its role in repolarizing the cardiac action potential. hERG alteration by mutation or pharmacological inhibition produces Long QT syndrome and the lethal cardiac arrhythmia torsade de pointes. W...
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| Publié dans: | Cell |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5484391/ https://ncbi.nlm.nih.gov/pubmed/28431243 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.03.048 |
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