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Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog

Effector memory T lymphocytes (T(EM) cells) that lack expression of CCR7 are major drivers of inflammation in a number of autoimmune diseases, including multiple sclerosis and rheumatoid arthritis. The Kv1.3 potassium channel is a key regulator of CCR7(−) T(EM) cell activation. Blocking Kv1.3 inhibi...

詳細記述

保存先:
書誌詳細
出版年:Clin Immunol
主要な著者: Tanner, Mark R., Tajhya, Rajeev B., Huq, Redwan, Gehrmann, Elizabeth J., Rodarte, Kathia E., Atik, Mustafa A., Norton, Raymond S., Pennington, Michael W., Beeton, Christine
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484050/
https://ncbi.nlm.nih.gov/pubmed/28389388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2017.03.014
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