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Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog
Effector memory T lymphocytes (T(EM) cells) that lack expression of CCR7 are major drivers of inflammation in a number of autoimmune diseases, including multiple sclerosis and rheumatoid arthritis. The Kv1.3 potassium channel is a key regulator of CCR7(−) T(EM) cell activation. Blocking Kv1.3 inhibi...
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出版年: | Clin Immunol |
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主要な著者: | , , , , , , , , |
フォーマット: | Artigo |
言語: | Inglês |
出版事項: |
2017
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5484050/ https://ncbi.nlm.nih.gov/pubmed/28389388 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2017.03.014 |
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