Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog

Effector memory T lymphocytes (T(EM) cells) that lack expression of CCR7 are major drivers of inflammation in a number of autoimmune diseases, including multiple sclerosis and rheumatoid arthritis. The Kv1.3 potassium channel is a key regulator of CCR7(−) T(EM) cell activation. Blocking Kv1.3 inhibi...

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Publicado no:Clin Immunol
Main Authors: Tanner, Mark R., Tajhya, Rajeev B., Huq, Redwan, Gehrmann, Elizabeth J., Rodarte, Kathia E., Atik, Mustafa A., Norton, Raymond S., Pennington, Michael W., Beeton, Christine
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484050/
https://ncbi.nlm.nih.gov/pubmed/28389388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2017.03.014
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