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Development of Highly Selective Kv1.3-Blocking Peptides Based on the Sea Anemone Peptide ShK
ShK, from the sea anemone Stichodactyla helianthus, is a 35-residue disulfide-rich peptide that blocks the voltage-gated potassium channel Kv1.3 at ca. 10 pM and the related channel Kv1.1 at ca. 16 pM. We developed an analog of this peptide, ShK-186, which is currently in Phase 1b-2a clinical trials...
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| Publicado no: | Mar Drugs |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4306950/ https://ncbi.nlm.nih.gov/pubmed/25603346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md13010529 |
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