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Analogs of the Sea Anemone Potassium Channel Blocker ShK for the Treatment of Autoimmune Diseases

CCR7(−) effector memory T (T(EM)) lymphocytes are involved in autoimmune diseases such as multiple sclerosis, type 1 diabetes mellitus and rheumatoid arthritis. These cells express Kv1.3 potassium channels that play a major role in their activation. Blocking these channels preferentially inhibits th...

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Hlavní autoři: Beeton, Christine, Pennington, Michael W., Norton, Raymond S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398462/
https://ncbi.nlm.nih.gov/pubmed/21824083
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