Conformational flexibility in the binding surface of the potassium channel blocker ShK

ShK is a 35-residue peptide that binds with high affinity to human voltage-gated potassium channels through a conserved K-Y dyad. Here we employ NMR measurements of backbone amide (15)N spin relaxation rates to investigate motions of the ShK backbone. Although ShK is rigid on the ps-ns timescale, in...

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Bibliografske podrobnosti
izdano v:Chembiochem
Main Authors: Sher, Inbal, Chang, Shih Chieh, Li, Ying, Chhabra, Sandeep, Palmer, Arthur G., Norton, Raymond S., Chill, Jordan H.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303621/
https://ncbi.nlm.nih.gov/pubmed/25236806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201402295
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