A Potent and Selective Peptide Blocker of the Kv1.3 Channel: Prediction from Free-Energy Simulations and Experimental Confirmation

The voltage-gated potassium channel Kv1.3 is a well-established target for treatment of autoimmune diseases. ShK peptide from a sea anemone is one of the most potent blockers of Kv1.3 but its application as a therapeutic agent for autoimmune diseases is limited by its lack of selectivity against oth...

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Detalhes bibliográficos
Main Authors: Rashid, M. Harunur, Heinzelmann, Germano, Huq, Redwan, Tajhya, Rajeev B., Chang, Shih Chieh, Chhabra, Sandeep, Pennington, Michael W., Beeton, Christine, Norton, Raymond S., Kuyucak, Serdar
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820677/
https://ncbi.nlm.nih.gov/pubmed/24244345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078712
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