NMR structures of double loops of an RNA aptamer against mammalian initiation factor 4A

A high affinity RNA aptamer (APT58, 58 nt long) against mammalian initiation factor 4A (eIF4A) requires nearly its entire nucleotide sequence for efficient binding. Since splitting either APT58 or eIF4A into two domains diminishes the affinity for each other, it is suggested that multiple interactio...

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Huvudupphovsmän: Sakamoto, Taiichi, Oguro, Akihiro, Kawai, Gota, Ohtsu, Takashi, Nakamura, Yoshikazu
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2005
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC548364/
https://ncbi.nlm.nih.gov/pubmed/15687383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki222
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