Characterisation of an aptamer against the Runt domain of AML1 (RUNX1) by NMR and mutational analyses

Since the invention of systematic evolution of ligands by exponential enrichment, many short oligonucleotides (or aptamers) have been reported that can bind to a wide range of target molecules with high affinity and specificity. Previously, we reported an RNA aptamer that shows high affinity to the...

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Bibliographic Details
Published in:FEBS Open Bio
Main Authors: Takada, Kenta, Amano, Ryo, Nomura, Yusuke, Tanaka, Yoichiro, Sugiyama, Shigeru, Nagata, Takashi, Katahira, Masato, Nakamura, Yoshikazu, Kozu, Tomoko, Sakamoto, Taiichi
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2018
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5794459/
https://ncbi.nlm.nih.gov/pubmed/29435416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12368
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