RNA aptamers to initiation factor 4A helicase hinder cap-dependent translation by blocking ATP hydrolysis

The mammalian translation initiation factor 4A (eIF4A) is a prototype member of the DEAD-box RNA helicase family that couples ATPase activity to RNA binding and unwinding. In the crystal form, eIF4A has a distended ‘‘dumbbell’’ structure consisting of two domains, which probably undergo a conformati...

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Main Authors: OGURO, AKIHIRO, OHTSU, TAKASHI, SVITKIN, YURI V., SONENBERG, NAHUM, NAKAMURA, YOSHIKAZU
Formato: Artigo
Idioma:Inglês
Publicado: Copyright 2003 by RNA Society 2003
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370407/
https://ncbi.nlm.nih.gov/pubmed/12649492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2161303
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