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RNA aptamers to initiation factor 4A helicase hinder cap-dependent translation by blocking ATP hydrolysis

The mammalian translation initiation factor 4A (eIF4A) is a prototype member of the DEAD-box RNA helicase family that couples ATPase activity to RNA binding and unwinding. In the crystal form, eIF4A has a distended ‘‘dumbbell’’ structure consisting of two domains, which probably undergo a conformati...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: OGURO, AKIHIRO, OHTSU, TAKASHI, SVITKIN, YURI V., SONENBERG, NAHUM, NAKAMURA, YOSHIKAZU
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Copyright 2003 by RNA Society 2003
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370407/
https://ncbi.nlm.nih.gov/pubmed/12649492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2161303
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