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RNA aptamers to initiation factor 4A helicase hinder cap-dependent translation by blocking ATP hydrolysis
The mammalian translation initiation factor 4A (eIF4A) is a prototype member of the DEAD-box RNA helicase family that couples ATPase activity to RNA binding and unwinding. In the crystal form, eIF4A has a distended ‘‘dumbbell’’ structure consisting of two domains, which probably undergo a conformati...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Copyright 2003 by RNA Society
2003
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1370407/ https://ncbi.nlm.nih.gov/pubmed/12649492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2161303 |
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