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High affinity RNA for mammalian initiation factor 4E interferes with mRNA-cap binding and inhibits translation
The eukaryotic translation initiation factor 4F (eIF4F) consists of three polypeptides (eIF4A, eIF4G, and eIF4E) and is responsible for recruiting ribosomes to mRNA. eIF4E recognizes the mRNA 5′-cap structure (m(7)GpppN) and plays a pivotal role in control of translation initiation, which is the rat...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Copyright 2005 by RNA Society
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1370693/ https://ncbi.nlm.nih.gov/pubmed/15611299 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.7108205 |
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