RNA aptamers to mammalian initiation factor 4G inhibit cap-dependent translation by blocking the formation of initiation factor complexes

Eukaryotic translation initiation factor 4G (eIF4G) plays a crucial multimodulatory role in mRNA translation and decay by interacting with other translation factors and mRNA-associated proteins. In this study, we isolated eight different RNA aptamers with high affinity to mammalian eIF4G by in vitro...

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Autores principales: Miyakawa, Shin, Oguro, Akihiro, Ohtsu, Takashi, Imataka, Hiroaki, Sonenberg, Nahum, Nakamura, Yoshikazu
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2006
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1581983/
https://ncbi.nlm.nih.gov/pubmed/16940549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2169406
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