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Engineered allosteric ribozymes that respond to specific divalent metal ions

In vitro selection was used to isolate five classes of allosteric hammerhead ribozymes that are triggered by binding to certain divalent metal ion effectors. Each of these ribozyme classes are similarly activated by Mn(2+), Fe(2+), Co(2+), Ni(2+), Zn(2+) and Cd(2+), but their allosteric binding site...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Zivarts, Maris, Liu, Yong, Breaker, Ronald R.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC548338/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15681614/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gki182
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