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Metal Binding Motif in the Active Site of the HDV Ribozyme Binds Divalent and Monovalent Ions

The hepatitis delta virus (HDV) ribozyme uses both metal ion and nucleobase catalysis in its cleavage mechanism. A reverse G•U wobble was observed in a recent crystal structure of the precleaved state. This unusual base pair positions a Mg(2+) ion to participate in catalysis. Herein, we used molecul...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Veeraraghavan, Narayanan, Ganguly, Abir, Chen, Jui-Hui, Bevilacqua, Philip C., Hammes-Schiffer, Sharon, Golden, Barbara L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2011
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3068245/
https://ncbi.nlm.nih.gov/pubmed/21348498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2000164
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