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Metal Binding Motif in the Active Site of the HDV Ribozyme Binds Divalent and Monovalent Ions
The hepatitis delta virus (HDV) ribozyme uses both metal ion and nucleobase catalysis in its cleavage mechanism. A reverse G•U wobble was observed in a recent crystal structure of the precleaved state. This unusual base pair positions a Mg(2+) ion to participate in catalysis. Herein, we used molecul...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3068245/ https://ncbi.nlm.nih.gov/pubmed/21348498 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2000164 |
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