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Identification of the Catalytic Mg(2+) Ion in the HDV Ribozyme
The hepatitis delta virus ribozyme catalyzes an RNA cleavage reaction using a catalytic nucleobase and a divalent metal ion. The catalytic base, C75, serves as a general acid and has a pK(a) shifted towards neutrality. Less is known about the role of metal ions in the mechanism. A recent crystal str...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3558840/ https://ncbi.nlm.nih.gov/pubmed/23311293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3013092 |
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