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A catalytic metal ion interacts with the cleavage site G•U wobble in the HDV ribozyme
The HDV ribozyme self-cleaves by a chemical mechanism involving general acid-base catalysis to generate a 2′,3′-cyclic phosphate and a 5′-hydroxyl termini. Biochemical studies from several laboratories have implicated C75 as the general acid and hydrated magnesium as the general base. We have previo...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2645270/ https://ncbi.nlm.nih.gov/pubmed/19178151 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8020108 |
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