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Mechanistic Strategies in the HDV Ribozyme: Chelated and Diffuse Metal Ion Interactions and Active Site Protonation

The crystal structure of the precleaved form of the hepatitis delta virus (HDV) ribozyme reveals two G•U wobbles near the active site: a rare reverse G•U wobble involving a syn G base, and a standard G•U wobble at the cleavage site. The catalytic mechanism for this ribozyme has been proposed to invo...

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Bibliografski detalji
Glavni autori: Veeraraghavan, Narayanan, Ganguly, Abir, Golden, Barbara L., Bevilacqua, Philip C., Hammes-Schiffer, Sharon
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3144556/
https://ncbi.nlm.nih.gov/pubmed/21644800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp203202e
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