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Thio Effects and an Unconventional Metal Ion Rescue in the Genomic HDV Ribozyme()
Metal ion and nucleobase catalysis are important for ribozyme mechanism, but the extent to which they cooperate is unclear. A crystal structure of the hepatitis delta virus (HDV) ribozyme suggested that the pro-R(P) oxygen at the scissile phosphate directly coordinates a catalytic Mg(2+) ion and is...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3825741/ https://ncbi.nlm.nih.gov/pubmed/24001219 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi4000673 |
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