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Inverse Thio Effects in the Hepatitis Delta Virus Ribozyme Reveal that the Reaction Pathway Is Controlled by Metal Ion Charge Density

[Image: see text] The hepatitis delta virus (HDV) ribozyme self-cleaves in the presence of a wide range of monovalent and divalent ions. Prior theoretical studies provided evidence that self-cleavage proceeds via a concerted or stepwise pathway, with the outcome dictated by the valency of the metal...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Thaplyal, Pallavi, Ganguly, Abir, Hammes-Schiffer, Sharon, Bevilacqua, Philip C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824481/
https://ncbi.nlm.nih.gov/pubmed/25799319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00190
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