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Engineered Allosteric Ribozymes that Sense the Bacterial Second Messenger c-di-GMP

A series of allosteric ribozymes that respond to the bacterial second messenger cyclic di-guanosyl-5′-monophosphate (c-di-GMP) have been created by using in vitro selection. An RNA library was generated by using random-sequence bridges to join a hammerhead self-cleaving ribozyme to an aptamer from a...

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Main Authors: Gu, Hongzhou, Furukawa, Kazuhiro, Breaker, Ronald R.
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140410/
https://ncbi.nlm.nih.gov/pubmed/22519888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac300415k
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