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Cooperative binding of effectors by an allosteric ribozyme

An allosteric ribozyme that requires two different effectors to induce catalysis was created using modular rational design. This ribozyme construct comprises five conjoined RNA modules that operate in concert as an obligate FMN- and theophylline-dependent molecular switch. When both effectors are pr...

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Библиографические подробности
Главные авторы: Jose, Antony M., Soukup, Garrett A., Breaker, Ronald R.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2001
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC31269/
https://ncbi.nlm.nih.gov/pubmed/11266567
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